| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 3 |
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| Ligand | BDBM50313336 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | 35S-GTPgammaS Binding |
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| pH | 7.4±n/a |
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| Temperature | 303.15±n/a K |
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| EC50 | >30000±n/a nM |
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| Comments | extracted |
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| Citation |  Bombrun, A; Schwarz, M; Crosignani, S; Covini, D; Marin, D 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis US Patent US9150519 Publication Date 10/6/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 3 |
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| Name: | Sphingosine 1-phosphate receptor 3 |
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| Synonyms: | C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42278.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99500 |
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| Residue: | 378 |
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| Sequence: | MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN
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|
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| BDBM50313336 |
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| n/a |
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| Name | BDBM50313336 |
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| Synonyms: | 6-(cyclohexylamino)-N-(2-methyl-4-sulfamoylphenyl)pyrimidine-4-carboxamide | CHEMBL1087142 | US9150519, 1-18 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N5O3S |
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| Mol. Mass. | 389.472 |
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| SMILES | Cc1cc(ccc1NC(=O)c1cc(NC2CCCCC2)ncn1)S(N)(=O)=O |
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| Structure | 
|
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