| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
|---|
| Ligand | BDBM184072 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | OX Inhibition Assay |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 2±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Bolli, M; Boss, C; Brotschi, C; Heidmann, B; Sifferlen, T; Williams, JT 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-YL)picolinamide derivatives as orexin receptor antagonists US Patent US9150566 Publication Date 10/6/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orexin/Hypocretin receptor type 1 |
|---|
| Name: | Orexin/Hypocretin receptor type 1 |
|---|
| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 47554.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O43613 |
|---|
| Residue: | 425 |
|---|
| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
|
|
|
|---|
| BDBM184072 |
|---|
| n/a |
|---|
| Name | BDBM184072 |
|---|
| Synonyms: | US9150566, 110 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H26N6O2 |
|---|
| Mol. Mass. | 454.5236 |
|---|
| SMILES | C[C@@H]1CN([C@H](Cc2cccc(c2)-c2ncccn2)CO1)C(=O)c1ccc(C)cc1-n1nccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
