| Reaction Details |
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 | Report a problem with these data |
| Target | Insulin receptor [964-1370] |
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| Ligand | BDBM184420 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DELFIA Assay |
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| pH | 7.4±n/a |
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| IC50 | 0.19±n/a nM |
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| Comments | extracted |
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| Citation |  Treu, M 5,8-dihydro-6H-pyrazolo[3,4-h]quinazolines as IGF-1R/IR inhibitors US Patent US9150578 Publication Date 10/6/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Insulin receptor [964-1370] |
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| Name: | Insulin receptor [964-1370] |
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| Synonyms: | INSR | INSR_HUMAN | Insulin-like growth factor 1 receptor (aa 964-1370) |
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| Type: | n/a |
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| Mol. Mass.: | 46101.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06213[964-1370] |
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| Residue: | 407 |
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| Sequence: | FVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKI
TLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTC
HHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEI
ADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM
APESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPE
RVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFED
MENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKN
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|
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| BDBM184420 |
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| n/a |
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| Name | BDBM184420 |
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| Synonyms: | US9150578, I-054 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31N9O |
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| Mol. Mass. | 509.6054 |
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| SMILES | COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(c2)C(C)C)n1 |
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| Structure | 
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