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TargetNeuronal acetylcholine receptor subunit alpha-4 beta 2
LigandBDBM50395217
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 0.12±n/a nM
Citation Carroll FIOndachi PWNavarro HADamaj MIWoods JHJutkiewicz EM Nicotinic receptor compounds US Patent  US9150581 Publication Date 10/6/2015
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-4 beta 2
Name:Neuronal acetylcholine receptor subunit alpha-4 beta 2
Synonyms:Neuronal acetylcholine receptor subunit alpha 4 subtype
Type:Enzyme
Mol. Mass.:70323.63
Organism:Rattus norvegicus (Rat)
Description:P09483-2
Residue:631
Sequence:
MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANI
SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELI
WRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK
FGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFI
IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPS
PTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLF
MKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAV
ETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQ
EAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKE
PSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAM
VIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50395217
n/a
NameBDBM50395217
Synonyms:CHEMBL2164667 | US9150581, RTI-7527-168
TypeSmall organic molecule
Emp. Form.C18H18FN3O
Mol. Mass.311.3534
SMILESNC(=O)c1ccc(cc1)-c1cc(cnc1F)C1CC2CCC1N2 |THB:11:16:19.20:22|
Structure
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