| Reaction Details |
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 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase |
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| Ligand | BDBM185115 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 59±n/a nM |
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| Comments | extracted |
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| Citation |  Brand, S; Wyatt, P; Thompson, S; Smith, V; Bayliss, T; Harrison, J; Norcross, N; Cleghorn, L; Gilbert, I; Brenk, R N-myristoyl transferase inhibitors US Patent US9156811 Publication Date 10/13/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Glycylpeptide N-tetradecanoyltransferase |
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| Name: | Glycylpeptide N-tetradecanoyltransferase |
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| Synonyms: | Glycylpeptide N-tetradecanoyltransferase | N-myristoyltransferase (NMT1) |
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| Type: | Protein |
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| Mol. Mass.: | 48514.36 |
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| Organism: | Leishmania major |
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| Description: | Q4Q5S8 |
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| Residue: | 421 |
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| Sequence: | MSRNPSNSDAAHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWT
PNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDWHVAVRRKADK
KLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEPRHICEINFLCVHKQLREKRL
APILIKEATRRVNRTNVWQAVYTAGVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQ
KFQNPMAMLKRNYQLPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHY
LLPRDGVVFTYVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLI
LDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPKIKPSQVALVM
L
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|
|
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| BDBM185115 |
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| n/a |
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| Name | BDBM185115 |
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| Synonyms: | US9156811, DDD100876 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N4O2S |
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| Mol. Mass. | 452.612 |
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| SMILES | CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc2CCN(C)Cc2c1 |
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| Structure | 
|
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