| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thyrotropin receptor |
|---|
| Ligand | BDBM60860 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Antagonist Activity Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Karstens, WF; Conti, PG; Timmers, CM; Plate, R; Van Koppen, CJ TSH receptor antagonizing tetrahydroquinoline compounds US Patent US9174940 Publication Date 11/3/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thyrotropin receptor |
|---|
| Name: | Thyrotropin receptor |
|---|
| Synonyms: | LGR3 | TSH-R | TSHR | TSHR_HUMAN | Thyroid stimulating hormone receptor | Thyroid-stimulating hormone receptor | Thyroid-stimulating hormone receptor (TSH) | Thyrotropin receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 86834.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P16473 |
|---|
| Residue: | 764 |
|---|
| Sequence: | MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI
ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD
ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL
TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTA
LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
CNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQE
DEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIV
VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSE
YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACA
IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCC
YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSK
ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQ
VQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
|
|
|
|---|
| BDBM60860 |
|---|
| n/a |
|---|
| Name | BDBM60860 |
|---|
| Synonyms: | US9174940, 31 |
|---|
| Type | n/a |
|---|
| Emp. Form. | C26H30N2O3 |
|---|
| Mol. Mass. | 418.528 |
|---|
| SMILES | CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)O[C@H]3CC4CC[C@H]3C4)ccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
