| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
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| Ligand | BDBM189805 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| IC50 | 413±n/a nM |
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| Citation |  Nazare, M; Halland, N; Schmidt, F; Weiss, T; Dietz, U; Hofmeister, A N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides and their use as pharmaceuticals US Patent US9174993 Publication Date 11/3/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Sgk1 |
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| Name: | Serine/threonine-protein kinase Sgk1 |
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| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 48954.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
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| Residue: | 431 |
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| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
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| BDBM189805 |
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| n/a |
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| Name | BDBM189805 |
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| Synonyms: | US9174993, 42 | US9221828, 42 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H12Cl2F4N6O4S2 |
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| Mol. Mass. | 647.409 |
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| SMILES | Fc1cc(F)c(cc1Cl)S(=O)(=O)Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(F)cc2F)cc1 |
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| Structure | 
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