| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium channel protein type 4 subunit alpha |
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| Ligand | BDBM190239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 15±n/a nM |
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| Citation |  Du Bois, J; Mulcahy, J; Andresen, B; Yeomans, DC; Biswal, S Methods and compositions for studying, imaging, and treating pain US Patent US9174999 Publication Date 11/3/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium channel protein type 4 subunit alpha |
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| Name: | Sodium channel protein type 4 subunit alpha |
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| Synonyms: | SCN4A_RAT | Scn4a | Sodium channel protein type IV alpha subunit | Voltage-gated sodium channel subunit alpha Nav1.4 | Voltage-gated sodium channel subunit alpha Nav1.4 (I757A) | Voltage-gated sodium channel subunit alpha Nav1.4 (M1240A) |
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| Type: | Enzyme |
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| Mol. Mass.: | 208810.50 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P15390 |
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| Residue: | 1840 |
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| Sequence: | MASSSLPNLVPPGPHCLRPFTPESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEA
GKNLPLIYGDPPPEVIGIPLEDLDPYYSDKKTFIVLNKGKAIFRFSATPALYLLSPFSIV
RRVAIKVLIHALFSMFIMITILTNCVFMTMSNPPSWSKHVEYTFTGIYTFESLIKMLARG
FCIDDFTFLRDPWNWLDFSVITMAYVTEFVDLGNISALRTFRVLRALKTITVIPGLKTIV
GALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMNDTNTTWYGNDTW
YSNDTWYGNDTWYINDTWNSQESWAGNSTFDWEAYINDEGNFYFLEGSNDALLCGNSSDA
GHCPEGYECIKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIF
FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDQEKEEEFQQMLEKYKKHQEELEKAK
AAQALESGEEADGDPTHNKDCNGSLDASGEKGPPRPSCSADSAISDAMEELEEAHQKCPP
WWYKCAHKVLIWNCCAPWVKFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHF
DNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANVQGLS
VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY
KECVCKIASDCNLPRWHMNDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVM
VIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKWGIGFAKTFLLGLLRG
KILSPKEIILSLGEPGGAGENAEESTPEDEKKEPPPEDKELKDNHILNHVGLTDGPRSSI
ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDAFSEPEDIKKPLQPLYDGNSSVCST
ADYKPPEEDPEEQAEENPEGEQPEECFTEACVKRCPCLYVDISQGRGKMWWTLRRACFKI
VEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFILEMLLKWVAY
GFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMR
VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCVNTTTSERFDISVVNNKS
ESESLMYTGQVRWMNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPHYEV
NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGKDIFMTEEQKKYYNAMKKLG
SKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVETDDQSQLKVDILYN
INMVFIIIFTGECVLKMFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLF
RVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYV
KKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTNVRGD
CGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLSEDDFEMFYETWEKF
DPDATQFIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEV
LGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSV
KQASYMYRHSQDGNDDGAPEKEGLLANTMNKMYGHEKEGDGVQSQGEEEKASTEDAGPTV
EPEPTSSSDTALTPSPPPLPPSSSPPQGQTVRPGVKESLV
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| BDBM190239 |
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| n/a |
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| Name | BDBM190239 |
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| Synonyms: | US9174999, Table 1, Compound 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H58N9O5 |
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| Mol. Mass. | 624.8383 |
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| SMILES | CCCCCC[N+](C)(C)CCCCCC(=O)NCCCCCCNC(=O)OC[C@@H]1NC(=N)N2CCC(O)(O)[C@@]22NC(=N)N[C@@H]12 |r| |
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| Structure | 
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