| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium channel protein type 4 subunit alpha [I757A] |
|---|
| Ligand | BDBM190235 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Binding Assay |
|---|
| IC50 | 700±n/a nM |
|---|
| Citation |  Du Bois, J; Mulcahy, J; Andresen, B; Yeomans, DC; Biswal, S Methods and compositions for studying, imaging, and treating pain US Patent US9174999 Publication Date 11/3/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium channel protein type 4 subunit alpha [I757A] |
|---|
| Name: | Sodium channel protein type 4 subunit alpha [I757A] |
|---|
| Synonyms: | SCN4A_RAT | Scn4a | Voltage-gated sodium channel subunit alpha Nav1.4 (I757A) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 208768.42 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P15390 (I757A) |
|---|
| Residue: | 1840 |
|---|
| Sequence: | MASSSLPNLVPPGPHCLRPFTPESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEA
GKNLPLIYGDPPPEVIGIPLEDLDPYYSDKKTFIVLNKGKAIFRFSATPALYLLSPFSIV
RRVAIKVLIHALFSMFIMITILTNCVFMTMSNPPSWSKHVEYTFTGIYTFESLIKMLARG
FCIDDFTFLRDPWNWLDFSVITMAYVTEFVDLGNISALRTFRVLRALKTITVIPGLKTIV
GALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMNDTNTTWYGNDTW
YSNDTWYGNDTWYINDTWNSQESWAGNSTFDWEAYINDEGNFYFLEGSNDALLCGNSSDA
GHCPEGYECIKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIF
FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDQEKEEEFQQMLEKYKKHQEELEKAK
AAQALESGEEADGDPTHNKDCNGSLDASGEKGPPRPSCSADSAISDAMEELEEAHQKCPP
WWYKCAHKVLIWNCCAPWVKFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHF
DNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANVQGLS
VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY
KECVCKIASDCNLPRWHMNDFFHSFLAVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVM
VIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKWGIGFAKTFLLGLLRG
KILSPKEIILSLGEPGGAGENAEESTPEDEKKEPPPEDKELKDNHILNHVGLTDGPRSSI
ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDAFSEPEDIKKPLQPLYDGNSSVCST
ADYKPPEEDPEEQAEENPEGEQPEECFTEACVKRCPCLYVDISQGRGKMWWTLRRACFKI
VEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFILEMLLKWVAY
GFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMR
VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCVNTTTSERFDISVVNNKS
ESESLMYTGQVRWMNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPHYEV
NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGKDIFMTEEQKKYYNAMKKLG
SKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVETDDQSQLKVDILYN
INMVFIIIFTGECVLKMFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLF
RVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYV
KKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTNVRGD
CGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLSEDDFEMFYETWEKF
DPDATQFIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEV
LGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSV
KQASYMYRHSQDGNDDGAPEKEGLLANTMNKMYGHEKEGDGVQSQGEEEKASTEDAGPTV
EPEPTSSSDTALTPSPPPLPPSSSPPQGQTVRPGVKESLV
|
|
|
|---|
| BDBM190235 |
|---|
| n/a |
|---|
| Name | BDBM190235 |
|---|
| Synonyms: | US9174999, Table 1, Compound 3 | US9174999, Table 1, Compound 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H27N7O4 |
|---|
| Mol. Mass. | 381.4301 |
|---|
| SMILES | OC1(O)CCN2C(=N)N[C@@H](COC(=O)NC3CCCCC3)[C@@H]3NC(=N)N[C@]123 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
