| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Arachidonate 15-lipoxygenase |
|---|
| Ligand | BDBM22873 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | LoxA HTP Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 1.01e+4± 3.3e+3 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Deschamps, JD; Ogunsola, AF; Jameson, JB; Yasgar, A; Flitter, BA; Freedman, CJ; Melvin, JA; Nguyen, JV; Maloney, DJ; Jadhav, A; Simeonov, A; Bomberger, JM; Holman, TR Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry55:3329-40 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Arachidonate 15-lipoxygenase |
|---|
| Name: | Arachidonate 15-lipoxygenase |
|---|
| Synonyms: | 15-Lipoxygenase (LoxA) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 74804.41 |
|---|
| Organism: | Pseudomonas aeruginosa |
|---|
| Description: | n/a |
|---|
| Residue: | 685 |
|---|
| Sequence: | MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNL
AGKLARRAVLTSKKLVYVWTENFGNVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNF
VASLPASAAAQFERIATGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIA
ILTRVGLLVDDILKSASNLVTQRGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVA
GPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAV
DKLLTGTGFAYAPIALFALGKDRARLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMA
KTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGA
ARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPLALPDYPY
RDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQL
VEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTL
VALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATI
RTRNQARRRPYEYLLPSRIPASTNI
|
|
|
|---|
| BDBM22873 |
|---|
| n/a |
|---|
| Name | BDBM22873 |
|---|
| Synonyms: | 1-(4-tert-butylphenyl)-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one | Bactil | CHEMBL305660 | Ebastine | Kestine | NCGC00164603 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H39NO2 |
|---|
| Mol. Mass. | 469.6576 |
|---|
| SMILES | CC(C)(C)c1ccc(cc1)C(=O)CCCN1CCC(CC1)OC(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
