| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Arachidonate 15-lipoxygenase |
|---|
| Ligand | BDBM26948 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | LoxA HTP Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 4.1e+3± 1.4e+3 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Deschamps, JD; Ogunsola, AF; Jameson, JB; Yasgar, A; Flitter, BA; Freedman, CJ; Melvin, JA; Nguyen, JV; Maloney, DJ; Jadhav, A; Simeonov, A; Bomberger, JM; Holman, TR Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry55:3329-40 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Arachidonate 15-lipoxygenase |
|---|
| Name: | Arachidonate 15-lipoxygenase |
|---|
| Synonyms: | 15-Lipoxygenase (LoxA) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 74804.41 |
|---|
| Organism: | Pseudomonas aeruginosa |
|---|
| Description: | n/a |
|---|
| Residue: | 685 |
|---|
| Sequence: | MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNL
AGKLARRAVLTSKKLVYVWTENFGNVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNF
VASLPASAAAQFERIATGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIA
ILTRVGLLVDDILKSASNLVTQRGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVA
GPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAV
DKLLTGTGFAYAPIALFALGKDRARLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMA
KTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGA
ARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPLALPDYPY
RDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQL
VEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTL
VALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATI
RTRNQARRRPYEYLLPSRIPASTNI
|
|
|
|---|
| BDBM26948 |
|---|
| n/a |
|---|
| Name | BDBM26948 |
|---|
| Synonyms: | 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | CHEMBL46516 | FLUSPIRILENE | NCGC00015424 | cid_3396 | med.21724, Compound Fluspirilene | spiropiperidine analogue, 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H31F2N3O |
|---|
| Mol. Mass. | 475.5727 |
|---|
| SMILES | Fc1ccc(cc1)C(CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
