Reaction Details |
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Target | Isoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N] |
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Ligand | BDBM152712 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Hemoglobin Capture Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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Ki | 116.5±0.0 nM |
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Comments | extracted |
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Citation | Li, H; Wang, HY; Kang, S; Silverman, RB; Poulos, TL Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase. Biochemistry55:3702-7 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Isoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N] |
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Name: | Isoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N] |
Synonyms: | Bnos | NOS1_RAT | Neuronal nitric oxide synthase mutant (D597N/M336V) | Nitric oxide synthase mutant (nNOS M336V/D597N) | Nitric oxide synthase, brain (PNNOS) [1-973,I269V,M336V,D597N] | Nos1 |
Type: | Protein |
Mol. Mass.: | 108435.83 |
Organism: | Rattus norvegicus (rats) |
Description: | Rat neuronal nitric oxide synthase mutant M336V/D597N |
Residue: | 973 |
Sequence: | MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAI
DPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLD
GKSHKAPPLGGDNDRVFNDLWGKDNVPVVLNNPYSEKEQSPTSGKQSPTKNGSPSRCPRF
LKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIVLPSQHTRKPEDVRTKDQLFPLAKE
FLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQ
WSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLI
RYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPEL
VLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRNYCD
NSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIK
HMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTN
GTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHA
FDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKY
PEPLRFFPRKGPSLSHVDSEAHSLVAARDSQHRSYKVRFNSVSSYSDSRKSSGDGPDLRD
NFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEA
FRTWAKKVFKAAC
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BDBM152712 |
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n/a |
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Name | BDBM152712 |
Synonyms: | 4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amino}pyridin-3-yl)ethyl]pyridin-2-amine (14) | US10759791, Compound 5 | US9951014, Name 14b | nNOS inhibitor, 2 |
Type | Small organic molecule |
Emp. Form. | C17H25N5 |
Mol. Mass. | 299.4139 |
SMILES | CNCCN(C)c1cncc(CCc2cc(C)cc(N)n2)c1 |
Structure |
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