| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf [V600E] |
|---|
| Ligand | BDBM192503 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | KiNativ assay |
|---|
| IC50 | 37±n/a nM |
|---|
| Citation |  Flynn, DL; Kaufman, MD; Vogeti, L; Wise, S; Lu, W; Smith, B; Caldwell, TM; Patt, WC; Henry, JR; Hipskind, PA; Peng, S Raf inhibitor compounds US Patent US9187474 Publication Date 11/17/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase B-raf [V600E] |
|---|
| Name: | Serine/threonine-protein kinase B-raf [V600E] |
|---|
| Synonyms: | B-RAF V600E | B-Raf (V600E) | B-Raf Protein Kinase Mutant (V600E) | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF (V600E) | BRAF mutant V600E | BRAF1 | BRAF_HUMAN | P15056 | Protein mono-ADP-ribosyltransferase (PARP3) | RAF serine/threonine protein kinase (V600E) | RAFB1 | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf (V600E) | Serine/threonine-protein kinase B-raf [V600E] | V-RAF murine sarcoma viral oncogene homologue B1 mutant (BRAF V600E) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 84474.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15056 V600E |
|---|
| Residue: | 766 |
|---|
| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATE
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
|
|
|
|---|
| BDBM192503 |
|---|
| n/a |
|---|
| Name | BDBM192503 |
|---|
| Synonyms: | US9187474, 18 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H28FN5O |
|---|
| Mol. Mass. | 409.4997 |
|---|
| SMILES | CNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)ccc1F |
|---|
| Structure | 
|
|---|
Search and Browse
