| Reaction Details |
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 | Report a problem with these data |
| Target | IspB protein |
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| Ligand | BDBM12578 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescent Assay |
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| IC50 | 2.2e+2± 1e+1 nM |
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| Citation |  Teng, KH; Hsu, ET; Chang, YH; Lin, SW; Liang, PH Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors. Biochemistry55:4366-74 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| IspB protein |
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| Name: | IspB protein |
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| Synonyms: | Octaprenyl diphosphate synthase (OPPS) |
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| Type: | Protein |
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| Mol. Mass.: | 35199.45 |
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| Organism: | Escherichia coli (Enterobacteria) |
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| Description: | n/a |
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| Residue: | 323 |
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| Sequence: | MNLEKINELTAQDMAGVNAAILEQLNSDVQLINQLGYYIVSGGGKRIRPMIAVLAARAVG
YEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKATANAAFGNAASVLVGDFIYTRAF
QMMTSLGSLKVLEVMSEAVNVIAEGEVLQLMNVNDPDITEENYMRVIYSKTARLFEAAAQ
CSGILAGCTPEEEKGLQDYGRYLGTAFQLIDDLLDYNADGEQLGKNVGDDLNEGKPTLPL
LHAMHHGTPEQAQMIRTAIEQGNGRHLLEPVLEAMNACGSLEWTRQRAEEEADKAIAALQ
VLPDTPWREALIGLAHIAVQRDR
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| BDBM12578 |
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| n/a |
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| Name | BDBM12578 |
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| Synonyms: | 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C5H10N2O7P2 |
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| Mol. Mass. | 272.0896 |
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| SMILES | OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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