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TargetMannosyl-oligosaccharide glucosidase
LigandBDBM193876
Substrate/Competitorn/a
Meas. Tech.α-Glucosidase inhibition assay
pH6.8±n/a
IC50 1.5824e+5± 3.41e+3 nM
Commentsextracted
Citation Özil, MEmirik, MEtlik, SYÜlker, SKahveci, B A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies. Bioorg Chem68:226-35 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mannosyl-oligosaccharide glucosidase
Name:Mannosyl-oligosaccharide glucosidase
Synonyms:CWH41 | CWH41_YEAST | GLS1 | alpha-Glucosidase (α-glucosidase)
Type:Protein
Mol. Mass.:96475.51
Organism:Saccharomyces cerevisiae (Yeast)
Description:n/a
Residue:833
Sequence:
MLISKSKMFKTFWILTSIVLLASATVDISKLQEFEEYQKFTNESLLWAPYRSNCYFGMRP
RYVHESPLIMGIMWFNSLSQDGLHSLRHFATPQDKLQKYGWEVYDPRIGGKEVFIDEKNN
LNLTVYFVKSKNGENWSVRVQGEPLDPKRPSTASVVLYFSQNGGEIDGKSSLAMIGHDGP
NDMKFFGYSKELGEYHLTVKDNFGHYFKNPEYETMEVAPGSDCSKTSHLSLQIPDKEVWK
ARDVFQSLVSDSIRDILEKEETKQRPADLIPSVLTIRNLYNFNPGNFHYIQKTFDLTKKD
GFQFDITYNKLGTTQSISTREQVTELITWSLNEINARFDKQFSFGEGPDSIESVEVKRRF
ALETLSNLLGGIGYFYGNQLIDRETEFDESQFTEIKLLNAKEEGPFELFTSVPSRGFFPR
GFYWDEGFHLLQIMEYDFDLAFEILASWFEMIEDDSGWIAREIILGNEARSKVPQEFQVQ
NPNIANPPTLLLAFSEMLSRAIENIGDFNSDSYHQVMFNSRTAKFMTNNLEANPGLLTEY
AKKIYPKLLKHYNWFRKSQTGLIDEYEEILEDEGIWDKIHKNEVYRWVGRTFTHCLPSGM
DDYPRAQPPDVAELNVDALAWVGVMTRSMKQIAHVLKLTQDEQRYAQIEQEVVENLDLLH
WSENDNCYCDISIDPEDDEIREFVCHEGYVSVLPFALKLIPKNSPKLEKVVALMSDPEKI
FSDYGLLSLSRQDDYFGKDENYWRGPIWMNINYLCLDAMRYYYPEVILDVAGEASNAKKL
YQSLKINLSNNIYKVWEEQGYCYENYSPIDGHGTGAEHFTGWTALVVNILGRF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM193876
n/a
NameBDBM193876
Synonyms:5-{[2-(2,4-Dichlorobenzyl)-1H-benzimidazol-1-yl]methyl}-N-phenyl-1,3,4-thiadiazol-2-amine (8a)
TypeSmall organic molecule
Emp. Form.C23H17Cl2N5S
Mol. Mass.466.386
SMILESClc1ccc(Cc2nc3ccccc3n2Cc2nnc(Nc3ccccc3)s2)c(Cl)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: