| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) |
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| Ligand | BDBM194216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization Assay |
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| Ki | 0.75±n/a nM |
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| Citation |  Cox, CD; Dudkin, VY; Kim, JJ; Kuduk, SD; McVean, CA; Reger, T; Sheen, JT; Steele, T Triazolyl PDE10 inhibitors US Patent US9200001 Publication Date 12/1/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) |
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| Name: | Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) |
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| Synonyms: | PDE10A | PDE10_HUMAN | Phosphodiesterase 10A | Phosphodiesterase 10A (PDE10A2) | Phosphodiesterase 10A2 | Phosphodiesterase 10A2 (PDE10A) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 89387.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y233-2 |
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| Residue: | 789 |
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| Sequence: | MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKAD
GFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG
PFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSV
AQKAAASED
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| BDBM194216 |
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| n/a |
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| Name | BDBM194216 |
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| Synonyms: | US9200001, 132 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22F2N8 |
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| Mol. Mass. | 436.4605 |
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| SMILES | Cc1nc(C)n(n1)-c1cc(nc(n1)N1CC(F)(F)C1)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r| |
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| Structure | 
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