| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
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| Ligand | BDBM194501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Spectrophotometric Assay |
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| pH | 7.4±n/a |
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| Ki | 200±40 nM |
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| Comments | extracted |
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| Citation |  De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
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| Synonyms: | HGXR_PLAFG | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) | LACZ |
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| Type: | Protein |
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| Mol. Mass.: | 26352.14 |
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| Organism: | Plasmodium falciparum |
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| Description: | P20035 |
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| Residue: | 231 |
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| Sequence: | MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQ
STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL
WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
|
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| BDBM194501 |
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| n/a |
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| Name | BDBM194501 |
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| Synonyms: | US9200020, Table 3 compound 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H20N6O5P |
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| Mol. Mass. | 347.2875 |
|---|
| SMILES | Nc1nc2n(CCN(CCO)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1 |
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| Structure | 
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