| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ADAM metallopeptidase with thrombospondin type 1 motif 4 |
|---|
| Ligand | BDBM194644 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AlphaScreen Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 2±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Durham, TB; Marimuthu, J; Wiley, MR Aggrecanase inhibitors US Patent US9206139 Publication Date 12/8/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ADAM metallopeptidase with thrombospondin type 1 motif 4 |
|---|
| Name: | ADAM metallopeptidase with thrombospondin type 1 motif 4 |
|---|
| Synonyms: | Metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 106624.01 |
|---|
| Organism: | Canis lupus familiaris (Dog) |
|---|
| Description: | A0A8I3Q3A2 |
|---|
| Residue: | 992 |
|---|
| Sequence: | MLKSAGARREAGKDSRGDPQTHRHGRERRRETETKAQRTKPETGQAQRKARQCEGHREAR
GAAGGTGRGRQRPGRGGGARGVWRSQATGRLSAAEGPGSLHLRRRSPAPLQTLPLTLAQV
RAPRLRRGVFQSRGGENLVRSRPPSLPGRGASAMAPTDRRPRRGLAGCWLWGAGPRLPLP
ALPTARPAARLLLPLLLSALLPSGRPAGPLPREEEIVFPERLNGSVPPGLGAPARLLCRL
PAFGETLLLELEQDPGVRVEGLTVQYLGRAPELLGGAEPGTYLTGSINGDPESVASLHWD
GGALLGVLQYRGTELHIQPLEGGSLNSAGGPGAHILRRKSPASGQGPMCNVKAPPGNPSP
SPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLV
VTRLVILGPGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVS
TCDTLGMADVGTVCDPARSCAVVEDDGLQSAFTAAHELGHVFNMLHDNSKSCADLNGPGS
TSRHVMAPVMAHVDPEEPWSPCSAHFITEFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDA
DRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGR
CLHVDQLQDFNIPQAGGWGPWGPWGDCSRSCGGGVQFSSRDCTRPVPRNGGKYCEGRRTR
FRSCNTQDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQA
RALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRVIGSKKKFDKCMVCGGDGSSC
SKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGTPGLRSLYLALKLPDGSYALNGEYTLM
PSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQNARLRYSFFVPRP
APATARPTPQDWLQRKAQILEILRRRPWAGRK
|
|
|
|---|
| BDBM194644 |
|---|
| n/a |
|---|
| Name | BDBM194644 |
|---|
| Synonyms: | US9206139, 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22F3N3O3 |
|---|
| Mol. Mass. | 409.4022 |
|---|
| SMILES | FC(F)(F)c1ccc(C[C@@H](C2CC2)C(=O)NC[C@]2(NC(=O)NC2=O)C2CC2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
