| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
|---|
| Ligand | BDBM194794 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Serotonin 5-HT2A Receptor Binding Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| Ki | 3.3±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Yamashita, H; Ito, N; Miyamura, S; Oshima, K; Matsubara, J; Kuroda, H; Takahashi, H; Shimizu, S; Tanaka, T Piperazine-substituted benzothiophenes for treatment of mental disorders US Patent US9206167 Publication Date 12/8/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 2A |
|---|
| Name: | 5-hydroxytryptamine receptor 2A |
|---|
| Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 52852.05 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Rat cortex membranes 5-HT2A receptors. |
|---|
| Residue: | 471 |
|---|
| Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
|
|
|
|---|
| BDBM194794 |
|---|
| n/a |
|---|
| Name | BDBM194794 |
|---|
| Synonyms: | US9206167, 15 | USRE48059, Compound of Example 15 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27N3O2S |
|---|
| Mol. Mass. | 433.566 |
|---|
| SMILES | O=C1CCc2ccc(OC\C=C\CN3CCN(CC3)c3cccc4sccc34)cc2N1 |
|---|
| Structure | 
|
|---|
Search and Browse
