| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Ligand | BDBM197716 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| pH | 7.8±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 3.9±0 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Li, Y; Rodgers, JD 3-[4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane—or heptane-nitrile as JAK inhibitors US Patent US9216984 Publication Date 12/22/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Name: | Tyrosine-protein kinase JAK1 [837-1142] |
|---|
| Synonyms: | JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 35230.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23458[837-1142] |
|---|
| Residue: | 306 |
|---|
| Sequence: | FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDP
EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIM
EFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ
VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT
YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQP
SNRTSF
|
|
|
|---|
| BDBM197716 |
|---|
| n/a |
|---|
| Name | BDBM197716 |
|---|
| Synonyms: | US9216984, 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H20N6 |
|---|
| Mol. Mass. | 308.3809 |
|---|
| SMILES | CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
