| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [828-1132] |
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| Ligand | BDBM197716 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| pH | 7.8±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.26±0 nM |
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| Comments | extracted |
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| Citation |  Li, Y; Rodgers, JD 3-[4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane—or heptane-nitrile as JAK inhibitors US Patent US9216984 Publication Date 12/22/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase JAK2 [828-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [828-1132] |
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| Synonyms: | JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 |
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| Type: | n/a |
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| Mol. Mass.: | 35579.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674[828-1132] |
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| Residue: | 305 |
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| Sequence: | GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER
IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEY
YKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGN
DKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR
DNMAG
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| BDBM197716 |
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| n/a |
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| Name | BDBM197716 |
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| Synonyms: | US9216984, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N6 |
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| Mol. Mass. | 308.3809 |
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| SMILES | CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12 |
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| Structure | 
|
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