| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Ligand | BDBM197771 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 59±n/a nM |
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| Comments | extracted |
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| Citation |  Kehler, J; Nielsen, J; Püschl, A; Kilburn, JP; Langgård, M Quinoline derivatives as PDE10A enzyme inhibitors US Patent US9216986 Publication Date 12/22/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Synonyms: | PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A) |
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| Type: | n/a |
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| Mol. Mass.: | 39060.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y233[440-779] |
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| Residue: | 340 |
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| Sequence: | ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLC
RFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRG
FSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKA
IIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTA
NDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTE
PLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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| BDBM197771 |
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| n/a |
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| Name | BDBM197771 |
|---|
| Synonyms: | US9216986, 7-Chloro-2-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-quinoline-6-carbonitrile |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15ClN6 |
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| Mol. Mass. | 362.816 |
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| SMILES | Cc1cnc(C)c2nc(CCc3ccc4cc(C#N)c(Cl)cc4n3)nn12 |
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| Structure | 
|
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