Reaction Details |
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Target | Kallikrein-1 |
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Ligand | BDBM200093 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Inhibition Assay |
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IC50 | 1200±n/a nM |
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Citation | Evans, DM; Davie, RL; Edwards, HJ; Rooker, DP Benzylamine derivatives as inhibitors of plasma kallikrein US Patent US9234000 Publication Date 1/12/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Kallikrein-1 |
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Name: | Kallikrein-1 |
Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
Type: | Enzyme |
Mol. Mass.: | 28874.69 |
Organism: | Homo sapiens (Human) |
Description: | P06870 |
Residue: | 262 |
Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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BDBM200093 |
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n/a |
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Name | BDBM200093 |
Synonyms: | US9234000, 84 |
Type | Small organic molecule |
Emp. Form. | C34H37ClN4O5S |
Mol. Mass. | 649.199 |
SMILES | CCOc1ccc(C[C@@H](NS(=O)(=O)c2ccc(Cl)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCc2ccc(CN)cc2)cc1 |
Structure |
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