Reaction Details |
| Report a problem with these data |
Target | Orexin receptor type 2 |
---|
Ligand | BDBM50447803 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro Assay: Intracellular Calcium Measurements |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 6±n/a nM |
---|
Comments | extracted |
---|
Citation | Aissaoui, H; Boss, C; Brotschi, C; Heidmann, B; Sifferlen, T; Williams, JT Lactam derivatives useful as orexin receptor antagonists US Patent US9242970 Publication Date 1/26/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Orexin receptor type 2 |
---|
Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
|
|
|
BDBM50447803 |
---|
n/a |
---|
Name | BDBM50447803 |
Synonyms: | CHEMBL3113753 | US9242970, 56 |
Type | Small organic molecule |
Emp. Form. | C22H23N3O3S |
Mol. Mass. | 409.501 |
SMILES | COc1ccnc(OC)c1C1CCCC(=O)N1Cc1csc(n1)-c1ccccc1 |
Structure |
|