| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50074060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay: Intracellular Calcium Measurements |
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| Temperature | 310.15±n/a K |
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| IC50 | 20±n/a nM |
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| Comments | extracted |
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| Citation |  Aissaoui, H; Boss, C; Brotschi, C; Heidmann, B; Sifferlen, T; Williams, JT Lactam derivatives useful as orexin receptor antagonists US Patent US9242970 Publication Date 1/26/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50074060 |
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| n/a |
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| Name | BDBM50074060 |
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| Synonyms: | CHEMBL3409869 | US9242970, 127 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23NO4 |
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| Mol. Mass. | 401.4544 |
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| SMILES | COc1cccc(OC)c1C1CCC(=O)N1Cc1ccc2oc3ccccc3c2c1 |
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| Structure | 
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