| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM203583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IMAP technology (Molecular Devices) |
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| pH | 7.2±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 5±n/a nM |
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| Comments | extracted |
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| Citation |  Seganish, WM; Brumfield, SN; Lim, J; Matasi, JJ; McElroy, WT; Tulshian, DB; Lavey, BJ; Altman, MD; Gibeau, CR; Lampe, JW; Methot, J; Zhu, L Aminopyrimidinones as interleukin receptor-associated kinase inhibitors US Patent US9221809 Publication Date 12/29/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM203583 |
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| n/a |
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| Name | BDBM203583 |
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| Synonyms: | US9221809, 141 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N8O2S |
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| Mol. Mass. | 518.634 |
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| SMILES | COc1ccc(nc1)N1CCN(CC1)c1nc(N[C@@H]2CCCNC2)c(-c2nc3ccccc3s2)c(=O)[nH]1 |r| |
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| Structure | 
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