| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) |
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| Ligand | BDBM204834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 4±n/a nM |
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| Citation |  Takeuchi, J; Ikura, M; Higashino, M; Iwahashi, M; Hashimura, K Trk-inhibiting compound US Patent US9242977 Publication Date 1/26/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) |
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| Name: | Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) |
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| Synonyms: | High affinity nerve growth factor receptor (TrkAI) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A (Trk-A) |
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| Type: | Enzyme |
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| Mol. Mass.: | 86881.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04629-2 |
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| Residue: | 790 |
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| Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAV
FACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL
QGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKAL
KEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP
DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI
GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ
PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ
APPVYLDVLG
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| BDBM204834 |
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| n/a |
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| Name | BDBM204834 |
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| Synonyms: | US9242977, 54 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H22F3N7O3S |
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| Mol. Mass. | 617.601 |
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| SMILES | FC(F)(F)c1cnc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc(s3)N3CCCC3=O)nc2)c1)-c1ccccc1 |
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| Structure | 
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