Reaction Details |
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Target | Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) |
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Ligand | BDBM204836 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 70±n/a nM |
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Citation | Takeuchi, J; Ikura, M; Higashino, M; Iwahashi, M; Hashimura, K Trk-inhibiting compound US Patent US9242977 Publication Date 1/26/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) |
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Name: | Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) |
Synonyms: | High affinity nerve growth factor receptor (TrkAI) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A (Trk-A) |
Type: | Enzyme |
Mol. Mass.: | 86881.47 |
Organism: | Homo sapiens (Human) |
Description: | P04629-2 |
Residue: | 790 |
Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAV
FACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL
QGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKAL
KEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP
DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI
GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ
PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ
APPVYLDVLG
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BDBM204836 |
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n/a |
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Name | BDBM204836 |
Synonyms: | US9242977, 59 |
Type | Small organic molecule |
Emp. Form. | C34H30F3N7O3S |
Mol. Mass. | 673.707 |
SMILES | Cc1ccc(cc1C)-c1ncc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCCCC2=O)nc1)C(F)(F)F |
Structure |
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