| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-enolase |
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| Ligand | BDBM204923 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enolase Enzymatic Assays |
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| pH | 7.4±n/a |
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| IC50 | 53.2±0.0 nM |
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| Comments | extracted |
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| Citation |  Leonard, PG; Satani, N; Maxwell, D; Lin, YH; Hammoudi, N; Peng, Z; Pisaneschi, F; Link, TM; Lee, GR; Sun, D; Prasad, BA; Di Francesco, ME; Czako, B; Asara, JM; Wang, YA; Bornmann, W; DePinho, RA; Muller, FL SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol12:1053-1058 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-enolase |
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| Name: | Alpha-enolase |
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| Synonyms: | 2-phospho-D-glycerate hydro-lyase | 4.2.1.11 | C-myc promoter-binding protein | ENO1 | ENO1L1 | ENOA_HUMAN | Enolase 1 | Enolase 1 (ENO1) | MBP-1 | MBPB1 | MPB-1 | MPB1 | NNE | Non-neural enolase | Phosphopyruvate hydratase | Plasminogen-binding protein |
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| Type: | n/a |
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| Mol. Mass.: | 47171.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06733 |
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| Residue: | 434 |
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| Sequence: | MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGK
GVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCK
AGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFRE
AMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKV
VIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDD
WGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLA
QANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSK
AKFAGRNFRNPLAK
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| BDBM204923 |
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| n/a |
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| Name | BDBM204923 |
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| Synonyms: | phosphonoacetohydroxamate (PhAH) |
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| Type | Small organic molecule |
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| Emp. Form. | C2H6NO5P |
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| Mol. Mass. | 155.0465 |
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| SMILES | ONC(=O)CP(O)(O)=O |
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| Structure | 
|
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