| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Probable manganese-dependent inorganic pyrophosphatase |
|---|
| Ligand | BDBM205472 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Colorimetric Malachite Green Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 1.09e+5± 1.6e+4 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Pang, AH; Garzan, A; Larsen, MJ; McQuade, TJ; Garneau-Tsodikova, S; Tsodikov, OV Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis. ACS Chem Biol11:3084-3092 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Probable manganese-dependent inorganic pyrophosphatase |
|---|
| Name: | Probable manganese-dependent inorganic pyrophosphatase |
|---|
| Synonyms: | Inorganic pyrophosphatase (SaPPiase) | PPAC_STAAR | ppaC |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 34052.80 |
|---|
| Organism: | Staphylococcus aureus (Firmicutes) |
|---|
| Description: | Q6GFD7 |
|---|
| Residue: | 309 |
|---|
| Sequence: | MAKTYIFGHKNPDTDAISSAIIMAEFEQLRGNSGAKAYRLGDVSAETQFALDTFNVPAPE
LLTDDLDGQDVILVDHNEFQQSSDTIASATIKHVIDHHRIANFETAGPLCYRAEPVGCTA
TILYKMFRERGFEIKPEIAGLMLSAIISDSLLFKSPTCTQQDVKAAEELKDIAKVDIQKY
GLDMLKAGASTTDKSVEFLLNMDAKSFTMGDYVTRIAQVNAVDLDEVLNRKEDLEKEMLA
VSAQEKYDLFVLVVTDIINSDSKILVVGAEKDKVGEAFNVQLEDDMAFLSGVVSRKKQIV
PQITEALTK
|
|
|
|---|
| BDBM205472 |
|---|
| n/a |
|---|
| Name | BDBM205472 |
|---|
| Synonyms: | PPiase inhibitor, 16 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H42N6 |
|---|
| Mol. Mass. | 474.684 |
|---|
| SMILES | CCCCN(CCCC)c1nc(nc(n1)-c1cccn1CCc1ccccc1)N1CCCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
