Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50015004 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Ligand Binding Assays |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 0.6±n/a nM |
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Comments | extracted |
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Citation | Lewis, J; Husbands, S Orvinol and thevinol derivatives useful in the treatment of depression US Patent US9259422 Publication Date 2/16/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50015004 |
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n/a |
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Name | BDBM50015004 |
Synonyms: | CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08026 | US9480684, 7a, R = 2- thienyl- BU08026 |
Type | Small organic molecule |
Emp. Form. | C29H35NO4S |
Mol. Mass. | 493.657 |
SMILES | [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@]([H])(C1)[C@](C)(O)c1cccs1)ccc3O |r,THB:10:9:17:4.5.6| |
Structure |
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