Reaction Details | |||
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Report a problem with these data | |||
Target | Mu-type opioid receptor | ||
Ligand | BDBM50090755 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Ligand Binding Assays | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
Ki | 0.16±n/a nM | ||
Comments | extracted | ||
Citation | Lewis, J; Husbands, S Orvinol and thevinol derivatives useful in the treatment of depression US Patent US9259422 Publication Date 2/16/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mu-type opioid receptor | |||
Name: | Mu-type opioid receptor | ||
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44503.11 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. | ||
Residue: | 398 | ||
Sequence: |
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BDBM50090755 | |||
n/a | |||
Name | BDBM50090755 | ||
Synonyms: | CHEMBL3581743 | US9259422, 22, R = 4-FPh- BU10120 | US9480684, 22, R = 4- FPh- BU10120 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H34FNO4 | ||
Mol. Mass. | 503.6044 | ||
SMILES | [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]51C[C@](C)([C@H](O)c4ccc(F)cc4)[C@]2(OC)C=C1)ccc3O |r,wU:17.21,16.16,19.23,1.0,wD:30.36,21.25,7.7,c:39,TLB:21:19:16.1:34.33,THB:10:9:17:4.5.6,20:19:16.1:34.33,(-3.17,.26,;-2.2,.57,;-3.38,2.21,;-2.2,3.8,;-.81,2.99,;.55,3.8,;1.94,2.99,;1.94,1.4,;2.83,1.9,;3.33,.57,;4.33,-.58,;5.84,-.3,;7.2,-.82,;6.92,.69,;2.73,2.15,;.51,2.18,;-.81,1.4,;.55,.57,;.55,-.99,;-.81,-1.79,;-1.89,-2.38,;.53,-2.51,;1.56,-1.84,;.61,-4.05,;-.68,-4.89,;-.6,-6.42,;.77,-7.12,;.84,-8.35,;2.06,-6.28,;1.98,-4.74,;-2.2,-.99,;-3.6,-1.56,;-4.57,-.8,;-.88,-.72,;-.88,.28,;.55,5.4,;-.81,6.2,;-2.2,5.4,;-3.26,6.01,)| | ||
Structure |