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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM209517 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <100±n/a nM | ||
| Comments | extracted | ||
| Citation |  Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
| ||
| BDBM209517 | |||
| n/a | |||
| Name | BDBM209517 | ||
| Synonyms: | US9271969, 5 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H26F3N3O4 | ||
| Mol. Mass. | 537.5296 | ||
| SMILES | OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)Nc1cccc(OC(F)(F)F)c1 |r,wD:4.3,(11.99,-3.85,;10.65,-3.08,;10.65,-1.54,;9.32,-3.85,;7.98,-3.08,;7.98,-1.54,;6.65,-.77,;5.32,-1.54,;5.32,-3.08,;6.65,-3.85,;3.98,-.77,;2.65,-1.54,;1.32,-.77,;1.32,.77,;2.65,1.54,;3.98,.77,;-.02,1.54,;-.02,3.08,;-1.35,3.85,;-2.69,3.08,;-4.15,3.56,;-5.06,2.31,;-4.15,1.06,;-2.69,1.54,;-1.35,.77,;-6.59,2.31,;-7.37,3.64,;-7.37,.98,;-8.91,.98,;-9.67,2.31,;-11.22,2.31,;-11.99,.98,;-11.22,-.36,;-11.99,-1.69,;-11.22,-3.02,;-10.45,-4.36,;-9.88,-2.25,;-12.55,-3.79,;-9.67,-.36,)| | ||
| Structure | 
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