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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM209545 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <250±n/a nM | ||
| Comments | extracted | ||
| Citation |  Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM209545 | |||
| n/a | |||
| Name | BDBM209545 | ||
| Synonyms: | US9271969, 33 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H25F4N3O3 | ||
| Mol. Mass. | 539.5207 | ||
| SMILES | OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)Nc1ccc(F)cc1C(F)(F)F |r,wD:4.3,(12.75,-5.95,;11.42,-5.18,;11.42,-3.64,;10.09,-5.95,;8.75,-5.18,;8.75,-3.64,;7.42,-2.87,;6.09,-3.64,;6.09,-5.18,;7.42,-5.95,;4.75,-2.87,;3.42,-3.64,;2.09,-2.87,;2.09,-1.33,;3.42,-.56,;4.75,-1.33,;.75,-.56,;.75,.98,;-.58,1.75,;-1.92,.98,;-3.38,1.46,;-4.28,.21,;-3.38,-1.03,;-1.92,-.56,;-.58,-1.33,;-5.82,.21,;-6.59,-1.12,;-6.59,1.55,;-8.13,1.55,;-8.9,.21,;-10.44,.21,;-11.21,1.55,;-12.75,1.55,;-10.44,2.88,;-8.83,3.01,;-8.06,4.34,;-7.29,5.67,;-9.4,5.11,;-6.73,3.57,)| | ||
| Structure | 
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