Ki Summary

Reaction Details

Report a problem with these data

Target

Tyrosine-protein kinase JAK2 [809-1153]

Ligand

BDBM185700

Substrate/Competitor

n/a

Meas. Tech.

JAK Enzymatic Assay

7.4±n/a

IC50

17.5±n/a nM

Comments

extracted

Citation

Mitton-Fry, MJ; Berlinski, PJ; Birchmeier, MJ; Bowman, JW; Gonzales, AJ; Kamerling, SG; Mann, DW Pyrrolo[2,3-D]pyrimidine compounds US Patent US9271981 Publication Date 3/1/2016

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK2 [809-1153]

Name:

Tyrosine-protein kinase JAK2 [809-1153]

Synonyms:

JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2

Type:

Protein

Mol. Mass.:

37870.86

Organism:

Homo sapiens (Human)

Description:

ThermoFisher Scientific, Cat no. PV4210 (809-1153 aa)

Residue:

324

Sequence:

FTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRY
DPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLI
MEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENEN
RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELF
TYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNN
NVNQRPSFRDLALRVDQIRDNMAG

BDBM185700

n/a

Name

BDBM185700

Synonyms:

US10875847, Compound Oclacitinib | US9161939, 1a | US9271981, 1a

Type

Small organic molecule

Emp. Form.

C15H23N5O2S

Mol. Mass.

337.44

SMILES

CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12 |r,wU:9.12,wD:6.5,(5.44,3.81,;3.9,3.81,;2.56,3.04,;1.79,1.7,;3.33,1.7,;1.23,3.81,;-.1,3.04,;-1.44,3.81,;-2.77,3.04,;-2.77,1.5,;-1.44,.73,;-.1,1.5,;-4.1,.73,;-5.44,1.5,;-4.1,-.81,;-5.44,-1.58,;-5.44,-3.12,;-4.1,-3.89,;-2.77,-3.12,;-1.31,-3.6,;-.4,-2.35,;-1.31,-1.11,;-2.77,-1.58,)|

Structure