| Reaction Details |
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 | Report a problem with these data |
| Target | D-3-phosphoglycerate dehydrogenase |
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| Ligand | BDBM209924 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PHGDH Enzyme Assay |
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| pH | 7.1±n/a |
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| IC50 | 3.48e+4± 3.6e+3 nM |
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| Comments | extracted |
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| Citation |  Wang, Q; Liberti, MV; Liu, P; Deng, X; Liu, Y; Locasale, JW; Lai, L Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol24:55-65 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D-3-phosphoglycerate dehydrogenase |
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| Name: | D-3-phosphoglycerate dehydrogenase |
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| Synonyms: | D-3-phosphoglycerate dehydrogenase | PGDH3 | PHGDH | Phosphoglycerate dehydrogenase (PHGDH) | SERA_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56650.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 533 |
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| Sequence: | MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQG
TSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGE
CLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPT
MIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
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| BDBM209924 |
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| n/a |
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| Name | BDBM209924 |
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| Synonyms: | PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-2101 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11N3O6 |
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| Mol. Mass. | 317.2536 |
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| SMILES | Oc1ccc(C(=O)N\N=C\c2cc(ccc2O)[N+]([O-])=O)c(O)c1 |
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| Structure | 
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