| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D-3-phosphoglycerate dehydrogenase [3-314] |
|---|
| Ligand | BDBM209924 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PHGDH Enzyme Assay |
|---|
| pH | 7.1±n/a |
|---|
| IC50 | 3.01e+4± 2.4e+3 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Wang, Q; Liberti, MV; Liu, P; Deng, X; Liu, Y; Locasale, JW; Lai, L Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol24:55-65 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D-3-phosphoglycerate dehydrogenase [3-314] |
|---|
| Name: | D-3-phosphoglycerate dehydrogenase [3-314] |
|---|
| Synonyms: | PGDH3 | PHGDH | Phosphoglycerate dehydrogenase N-terminal fragment (PHGDH fragment) | SERA_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 33421.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | PHGDH N-terminal fragment (3-314 aa) |
|---|
| Residue: | 312 |
|---|
| Sequence: | FANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTAD
VINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIP
QATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEV
SASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDE
GALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQ
FVDMVKGKSLTG
|
|
|
|---|
| BDBM209924 |
|---|
| n/a |
|---|
| Name | BDBM209924 |
|---|
| Synonyms: | PKUMDL-WQ-2101 | US10722489, Compound PKUMDL-WL-2101 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H11N3O6 |
|---|
| Mol. Mass. | 317.2536 |
|---|
| SMILES | Oc1ccc(C(=O)N\N=C\c2cc(ccc2O)[N+]([O-])=O)c(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
