| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A |
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| Ligand | BDBM67628 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Aurora A Activity Assay (DiscoverX) |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 423.0±66 nM |
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| Comments | extracted |
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| Citation |  Sebti, SM; Schönbrunn, E; Lawrence, NJ; Lawrence, HR; Martin, MP Aurora kinase inhibitors and methods of making and using thereof US Patent US9249124 Publication Date 2/2/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Aurora kinase A |
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| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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|
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| BDBM67628 |
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| n/a |
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| Name | BDBM67628 |
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| Synonyms: | (2-anilinopyrimidin-4-yl)-phenyl-amine | 2-N,4-N-diphenylpyrimidine-2,4-diamine | MLS000767870 | N*2*,N*4*-Diphenyl-pyrimidine-2,4-diamine | N2,N4-diphenylpyrimidine-2,4-diamine | SMR000430199 | US9249124, 7 | cid_948954 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14N4 |
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| Mol. Mass. | 262.3092 |
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| SMILES | N(c1ccccc1)c1ccnc(Nc2ccccc2)n1 |
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| Structure | 
|
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