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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Endoplasmin | ||
| Ligand | BDBM210943 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Polarization (FP) Assay | ||
| pH | 7.3±n/a | ||
| Kd | 2.94e+3± 2.7e+2 nM | ||
| Comments | extracted | ||
| Citation |  Mishra, SJ; Ghosh, S; Stothert, AR; Dickey, CA; Blagg, BS Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold. ACS Chem Biol12:244-253 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Endoplasmin | |||
| Name: | Endoplasmin | ||
| Synonyms: | 94 kDa glucose-regulated protein | ENPL_HUMAN | GRP-94 | GRP94 | Glucose regulated protein 94kDa (Grp94) | HSP90B1 | Heat shock protein 90 kDa beta member 1 | TRA1 | Tumor rejection antigen 1 | gp96 homolog | ||
| Type: | Protein | ||
| Mol. Mass.: | 92417.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P14625 | ||
| Residue: | 803 | ||
| Sequence: |
| ||
| BDBM210943 | |||
| n/a | |||
| Name | BDBM210943 | ||
| Synonyms: | 4-(2-(2-chlorophenyl)-1H-pyrrol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide (5e) | US10975030, Compound 5e | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24ClN3O2 | ||
| Mol. Mass. | 409.909 | ||
| SMILES | NC(=O)c1ccc(cc1NC1CCC(O)CC1)-n1cccc1-c1ccccc1Cl |(2.67,4.62,;1.33,3.85,;,4.62,;1.33,2.31,;,1.54,;;1.33,-.77,;2.67,,;2.67,1.54,;4,2.31,;5.33,1.54,;6.67,2.31,;8,1.54,;8,,;9.34,-.77,;6.67,-.77,;5.33,,;1.33,-2.31,;2.58,-3.22,;2.1,-4.68,;.56,-4.68,;.09,-3.22,;-1.38,-2.74,;-1.7,-1.23,;-3.16,-.76,;-4.31,-1.79,;-3.99,-3.29,;-2.52,-3.77,;-2.2,-5.28,)| | ||
| Structure | 
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