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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Endoplasmin | ||
| Ligand | BDBM210948 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Polarization (FP) Assay | ||
| pH | 7.3±n/a | ||
| Kd | 1.32e+4± 1.2e+2 nM | ||
| Comments | extracted | ||
| Citation |  Mishra, SJ; Ghosh, S; Stothert, AR; Dickey, CA; Blagg, BS Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold. ACS Chem Biol12:244-253 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Endoplasmin | |||
| Name: | Endoplasmin | ||
| Synonyms: | 94 kDa glucose-regulated protein | ENPL_HUMAN | GRP-94 | GRP94 | Glucose regulated protein 94kDa (Grp94) | HSP90B1 | Heat shock protein 90 kDa beta member 1 | TRA1 | Tumor rejection antigen 1 | gp96 homolog | ||
| Type: | Protein | ||
| Mol. Mass.: | 92417.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P14625 | ||
| Residue: | 803 | ||
| Sequence: |
| ||
| BDBM210948 | |||
| n/a | |||
| Name | BDBM210948 | ||
| Synonyms: | 2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(2-(pyridin-4-yl)-1H-pyrrol-1-yl)benzamide (5j) | US10975030, Compound 5j | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24N4O2 | ||
| Mol. Mass. | 376.4516 | ||
| SMILES | NC(=O)c1ccc(cc1NC1CCC(O)CC1)-n1cccc1-c1ccncc1 |(9.14,6.59,;7.8,5.82,;6.47,6.59,;7.8,4.28,;6.47,3.51,;6.47,1.97,;7.8,1.2,;9.14,1.97,;9.14,3.51,;10.47,4.28,;11.8,3.51,;13.14,4.28,;14.47,3.51,;14.47,1.97,;15.8,1.2,;13.14,1.2,;11.8,1.97,;7.8,-.34,;9.05,-1.25,;8.57,-2.71,;7.03,-2.71,;6.56,-1.25,;5.09,-.77,;4.77,.73,;3.31,1.21,;2.16,.18,;2.48,-1.33,;3.95,-1.8,)| | ||
| Structure | 
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