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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Endoplasmin | ||
| Ligand | BDBM210957 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Polarization (FP) Assay | ||
| pH | 7.3±n/a | ||
| Kd | 1.29e+4± 1.1e+2 nM | ||
| Comments | extracted | ||
| Citation |  Mishra, SJ; Ghosh, S; Stothert, AR; Dickey, CA; Blagg, BS Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold. ACS Chem Biol12:244-253 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Endoplasmin | |||
| Name: | Endoplasmin | ||
| Synonyms: | 94 kDa glucose-regulated protein | ENPL_HUMAN | GRP-94 | GRP94 | Glucose regulated protein 94kDa (Grp94) | HSP90B1 | Heat shock protein 90 kDa beta member 1 | TRA1 | Tumor rejection antigen 1 | gp96 homolog | ||
| Type: | Protein | ||
| Mol. Mass.: | 92417.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P14625 | ||
| Residue: | 803 | ||
| Sequence: |
| ||
| BDBM210957 | |||
| n/a | |||
| Name | BDBM210957 | ||
| Synonyms: | 4-(2-(2-bromobenzyl)-1H-pyrrol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide (8h) | US10975030, Compound 8h | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26BrN3O2 | ||
| Mol. Mass. | 468.386 | ||
| SMILES | NC(=O)c1ccc(cc1NC1CCC(O)CC1)-n1cccc1Cc1ccccc1Br |(2.47,4.51,;3.8,3.74,;5.14,4.51,;3.8,2.2,;2.47,1.43,;2.47,-.11,;3.8,-.88,;5.14,-.11,;5.14,1.43,;6.47,2.2,;7.8,1.43,;9.14,2.2,;10.47,1.43,;10.47,-.11,;11.8,-.88,;9.14,-.88,;7.8,-.11,;3.8,-2.42,;2.56,-3.33,;3.03,-4.79,;4.57,-4.79,;5.05,-3.33,;6.51,-2.85,;7.66,-3.88,;7.34,-5.39,;8.48,-6.42,;9.95,-5.95,;10.27,-4.44,;9.12,-3.41,;9.44,-1.9,)| | ||
| Structure | 
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