| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM211514 |
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| Substrate/Competitor | BDBM211682 |
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| Meas. Tech. | Human Neutrophil Elastase Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.3±n/a nM |
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| Comments | extracted |
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| Citation |  Peters, S; Anderskewitz, R; Morschhaeuser, G; Oost, T Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent US9290457 Publication Date 3/22/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM211514 |
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| BDBM211682 |
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| Name | BDBM211514 |
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| Synonyms: | US9290457, Example 1.56 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H25F3N6O3 |
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| Mol. Mass. | 550.5317 |
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| SMILES | CN(Cc1cn[nH]c1)C(=O)c1cc(ccc1C1N(C)C(=O)N(C(C)=C1C(C)=O)c1cccc(c1)C(F)(F)F)C#N |c:25| |
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| Structure | 
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