| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM212442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhbition Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 7.3±n/a nM |
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| Comments | extracted |
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| Citation |  Ali, A; Bey, E; Hartmann, R; Hu, Q; Yin, L Aldosterone synthase inhibitors US Patent US9278093 Publication Date 3/8/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 57582.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19099 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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|
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| BDBM212442 |
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| n/a |
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| Name | BDBM212442 |
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| Synonyms: | US9278093, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16F2N4 |
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| Mol. Mass. | 338.3539 |
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| SMILES | Cc1nnc2CCc3cc(cc(F)c3-n12)-c1cncc(F)c1C1CC1 |
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| Structure | 
|
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