Reaction Details |
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Target | Cytochrome P450 11B2, mitochondrial |
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Ligand | BDBM212443 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhbition Assay |
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Temperature | 310.15±n/a K |
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IC50 | 9.5±n/a nM |
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Comments | extracted |
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Citation | Ali, A; Bey, E; Hartmann, R; Hu, Q; Yin, L Aldosterone synthase inhibitors US Patent US9278093 Publication Date 3/8/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B2, mitochondrial |
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Name: | Cytochrome P450 11B2, mitochondrial |
Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
Type: | Protein |
Mol. Mass.: | 57582.15 |
Organism: | Homo sapiens (Human) |
Description: | P19099 |
Residue: | 503 |
Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM212443 |
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n/a |
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Name | BDBM212443 |
Synonyms: | US9278093, 3 |
Type | Small organic molecule |
Emp. Form. | C19H18F2N4 |
Mol. Mass. | 340.3698 |
SMILES | CC(C)c1c(F)cncc1-c1cc(F)c-2c(CCc3nnc(C)n-23)c1 |
Structure |
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