| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
|---|
| Ligand | BDBM212444 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhbition Assay |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 9802±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ali, A; Bey, E; Hartmann, R; Hu, Q; Yin, L Aldosterone synthase inhibitors US Patent US9278093 Publication Date 3/8/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B1, mitochondrial |
|---|
| Name: | Cytochrome P450 11B1, mitochondrial |
|---|
| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 57591.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P15538 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
|
|
|
|---|
| BDBM212444 |
|---|
| n/a |
|---|
| Name | BDBM212444 |
|---|
| Synonyms: | US9278093, 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H11ClF2N4 |
|---|
| Mol. Mass. | 332.735 |
|---|
| SMILES | Cc1nnc2CCc3cc(cc(F)c3-n12)-c1cncc(F)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
