| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
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| Ligand | BDBM213161 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC Enzyme Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 24±n/a nM |
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| Comments | extracted |
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| Citation |  van Duzer, JH; Mazitschek, R; Jones, SS; Yang, M; Tamang, DL Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors US Patent US9278963 Publication Date 3/8/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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|
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| BDBM213161 |
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| n/a |
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| Name | BDBM213161 |
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| Synonyms: | US9278963, 008 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N6O4 |
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| Mol. Mass. | 462.501 |
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| SMILES | COc1ccc(NC(=O)N2CCC(CC2)(Nc2ncc(cn2)C(=O)NO)c2ccccc2)cc1 |
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| Structure | 
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