| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase TTK |
|---|
| Ligand | BDBM213798 |
|---|
| Substrate/Competitor | Biotinylated Peptide |
|---|
| Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
|---|
| pH | 7.7±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| IC50 | 72.3±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Koppitz, M; Klar, U; Jautelat, R; Kosemund, D; Bohlmann, R; Bader, B; Lienau, P; Siemeister, G Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors US Patent US9284317 Publication Date 3/15/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase TTK |
|---|
| Name: | Dual specificity protein kinase TTK |
|---|
| Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 97086.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P33981 |
|---|
| Residue: | 857 |
|---|
| Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
|
|
|
|---|
| BDBM213798 |
|---|
| Biotinylated Peptide |
|---|
| Name: | Biotinylated Peptide |
|---|
| Synonyms: | n/a |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 1551.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Purchased from Biosynthan GmbH, Berlin |
|---|
| Residue: | 14 |
|---|
| Sequence: | |
|---|
Search and Browse
