| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter [P314L] |
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| Ligand | BDBM50017701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | [3H]TBZOH Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | >200±0 nM |
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| Kd | >100±0 nM |
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| Comments | extracted |
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| Citation |  Ugolev, Y; Segal, T; Yaffe, D; Gros, Y; Schuldiner, S Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine. J Biol Chem288:32160-71 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter [P314L] |
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| Name: | Synaptic vesicular amine transporter [P314L] |
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| Synonyms: | Slc18a2 | Svat | VMAT2_RAT | Vesicular monoamine transporter 2 (VMAT P314L) | Vmat2 |
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| Type: | Protein |
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| Mol. Mass.: | 55705.63 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Rat VMAT2 P314L mutant |
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| Residue: | 515 |
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| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLELALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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| BDBM50017701 |
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| n/a |
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| Name | BDBM50017701 |
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| Synonyms: | 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one | 3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one | CHEMBL117785 | TETRABENAZINE | Tetrabenazine (TBZ) |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27NO3 |
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| Mol. Mass. | 317.4226 |
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| SMILES | COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC |
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| Structure | 
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