Reaction Details |
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Target | Synaptic vesicular amine transporter [P314T] |
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Ligand | BDBM50017701 |
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Substrate/Competitor | n/a |
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Meas. Tech. | [3H]TBZOH Binding Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | >200±0 nM |
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Kd | >100±0 nM |
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Comments | extracted |
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Citation | Ugolev, Y; Segal, T; Yaffe, D; Gros, Y; Schuldiner, S Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine. J Biol Chem288:32160-71 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Synaptic vesicular amine transporter [P314T] |
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Name: | Synaptic vesicular amine transporter [P314T] |
Synonyms: | Slc18a2 | Svat | VMAT2_RAT | Vesicular monoamine transporter 2 (VMAT P314T) | Vmat2 |
Type: | Protein |
Mol. Mass.: | 55693.57 |
Organism: | Rattus norvegicus (Rat) |
Description: | Rat VMAT2 P314T mutant |
Residue: | 515 |
Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLETALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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BDBM50017701 |
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n/a |
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Name | BDBM50017701 |
Synonyms: | 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one | 3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one | CHEMBL117785 | TETRABENAZINE | Tetrabenazine (TBZ) |
Type | Small organic molecule |
Emp. Form. | C19H27NO3 |
Mol. Mass. | 317.4226 |
SMILES | COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC |
Structure |
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