| Reaction Details |
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 | Report a problem with these data |
| Target | Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] |
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| Ligand | BDBM214650 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MKNK1 Kinase High ATP Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 34±n/a nM |
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| Comments | extracted |
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| Citation |  Eis, K; Pühler, F; Zorn, L; Scholz, A; Lienau, P; Gnoth, MJ; Bömer, U; Günther, J; Fanghänel, J; Korr, D Heterocyclyl aminoimidazopyridazines US Patent US9284319 Publication Date 3/15/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] |
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| Name: | Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] |
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| Synonyms: | GST-MKNK1 | Glutathione S-transferase A1/MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glutathione S-transferase A1 |
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| Synonyms: | GST class-alpha member 1 | GST-epsilon | GSTA1 | GSTA1-1 | GSTA1_HUMAN | GTH1 | Glutathione S-transferase (GST) | HA subunit 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 25636.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glutathione-S-Transferase (GST, N-terminally) |
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| Residue: | 222 |
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| Sequence: | MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK
LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
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| Component 2 |
| Name: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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| Synonyms: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase signal-integrating kinase 1 (MNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)(T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase-interacting serine/threonine-protein kinase 1 (T344D) | MKNK1 | MKNK1 (aa 1-424) T344D | MKNK1_HUMAN | MNK1 | MNK1a |
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| Type: | Protein |
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| Mol. Mass.: | 47416.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BUB5-2 with T344D |
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| Residue: | 424 |
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| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPDPQVLQRNSSTMDLTLF
AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP
PTAL
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| BDBM214650 |
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| n/a |
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| Name | BDBM214650 |
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| Synonyms: | US10688093, Compound 229_0237_0073 | US11701353, Compound 229_0237_0073 | US9284319, R8 | US9730929, Example R8 | US9783543, R8 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N5O |
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| Mol. Mass. | 341.366 |
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| SMILES | C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccncc1 |
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| Structure | 
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